George Clooney
While some might think George Clooney's career began with ER, they are sorely mistaken. Before he was Dr. Doug Ross, Clooney starred in two low-budget '80s slasher flicks: Return to Horror High (1987) and Return of the Killer Tomatoes (1988). Film critic Steve Miller wrote of Return to Horror High, "The narrative threads of this low-budget spoof of slasher films are more tangled than the cocaine-fueled fever dreams of Quentin Tarantino."
Patricia Arquette
The Arquette family is no stranger to the horror genre—not only did David have a recurring role in the Scream franchise, but Patricia got her start as a final girl. Arquette played Kristen Parker in A Nightmare on Elm Street 3: Dream Warriors (1987). To the chagrin of many fans, Arquette didn't return for A Nightmare on Elm Street 4: The Dream Master (1988), instead choosing to pursue other opportunities.