Adam Scott
Before Adam Scott was the mayor of Ice Town, his first major film role was that of Jacques in the fourth Hellraiser installment, Hellraiser: Bloodline. Scott's role was originally much smaller, but he was rewritten and expanded upon to compensate for Angelique's origin change. The movie was so terrible that director Kevin Yagher had his name removed from the credits.
Angela Bassett
Surprisingly, Leonardo DiCaprio wasn't the only one whose career was jumpstarted by the Critters franchise. Angela Bassett played a pilot named Fran in Critters 4 (1992), which began where DiCaprio's Critters 3 left off. In all likelihood, Bassett's career was kickstarted by her performance in Boyz n the Hood (1991) rather than a Critters sequel that took place in space.