Brian George as Dr. V.M. Koothrappali
Raj's hilarious father, the highly-regarded gynecologist Dr. V.M. Koothrappali, was played by Brian George. Dr. Koothrappali was usually seen over video chat because Raj's parents lived and worked in New Delhi. The Israeli-English actor is also known for his performance as Babu Bhatt on Seinfeld.
Carol Ann Susi as Debbie Wolowitz
Although she always remained offscreen, Debbie Wolowitz was integral to the show throughout the years. Carol Ann Susi sadly passed away from lung cancer in 2014 at the age of 62. In Susi's honor, the character passed away as well, and the actors worked to express their grief over the very real loss.