Matthew McConaughey
McConaughey played a Texas AIDS patient who was given 30 days to live in the movie Dallas Buyers Club. In order to look like a man who was dying from an advanced auto-immune disease, he was forced to restrict his caloric intake by roughly 70%, and he had to burn an additional 1,800 calories a day from a strict exercise routine.
He's Going the Distance
McConaughey's wife helped him cut back on calories by preparing his meals for him. His goal was to drop four pounds per week, and at the end of his run, he had lost a grand total of 47 pounds. That being said, he visited doctors regularly to make sure that his weight loss was healthy and reversible.