Brandon Routh
Routh had a penitent for persistence and landed himself roles on Gilmore Girls and Chuck in the 2000s. He also played a supporting role in Zack and Miri Make a Porno and Scott Pilgrim vs. the World.
Superman Returns
Routh's biggest role was arguably in Bryan Singer's Superman Returns in 2006. Despite the buildup to the huge role, the film did poorly at the box offices. Looks like it takes a special actor to replace Christopher Reeve, and Routh wasn't it.