Before the Beatles existed, before the Rolling Stones even decided to try making music, Chuck Berry was changing the world with his artistic interpretation of how a guitar should be played. He was the original frontman, his showmanship was truly unique, so much so that it was shunned initially. Much like other great innovators, Berry's career began with people disliking him for being different, bold, energetic, spastic even. He coined the act of playing the guitar behind the head, between the legs, and virtually every other coveted move that has been replicated over and over until it became commonplace for every guitarist to try at least once. Chuck Berry isn't just a legend, he is THE legend.
Dean Ween
Dean Ween is the pride of Pennsylvania, and quite possibly the pride of music as a whole. Ween is one of the most innovative and charismatic bands of all time, and they have literally pushed the genre of rock and roll further than any other band that has existed.
Hailing from New Hope, Ween hit the scene with a bang in the mid-1980s. Howard Stern and Henry Rollins put Ween onto the big scene, claiming that their defiance of traditional punk rock conventions was the most punk thing about music, period. Since then, Ween has never really become that famous. Despite inspiring one of the most popular cartoons in history (Spongebob Squarepants), and having several popular singles, Ween has maintained a cult following regarding their discography, which is laden with gospel, folk, country, funk, rock, punk, heavy metal, and electronic songs slipping over from album to album. Dean Ween never set a prospect for the band, he just played guitar and everyone else followed along. The genius behind Ween stems from an unwillingness to conform to a traditional standard, and raw instrumental talent.
Henry Rollins
Henry Rollins was the reason Punk was alive. His competitive nature inspired dozens, if not hundreds of similar artists to try and do what he was doing. The keyword here is "Try."