Julianna Margulies vs. Archie Panjabi
These two played best friends on the show The Good Wife. The relationship of the characters was broken when one slept with the other's husband. In reality, Margulies and Panjabi began avoiding each other off the set and stopped talking. They never admitted to avoiding each other, but some rumors were spreading that they got too invested in the roles. The emotions got too real!
Patrick Swayze and Jennifer Grey
Patrick Swayze and Jennifer Grey captivated 1980s film fans. Their love story defined the decade, after all. In Swayze's autobiography, he wrote that Grey was difficult to work with, couldn't keep her composure, and would often mess up her lines and scenes. Ouch.