George Clooney and Julia Roberts
People began to speculate that Clooney and Roberts had a falling out due to Roberts getting dropped from the Oceans 13 line-up. Rumors began to swirl claiming that Roberts was hesitant to sign onto the contract because of Clooney. According to the director, Steven Soderbergh, Roberts's character was dropped from the storyline because they wanted to take the plot in a different direction. No bad blood there!
David Duchovny and Gillian Anderson
While fans thought that Scully and Mulder had insane on-screen chemistry, Duchovny and Anderson had the complete opposite. They had a great friendship at the beginning of filming The X-Files, but their relationship was strained near the end. Both have said that the stress from filming made them "monsters."