Schindler's List
Spielberg's most moving film is possibly Schindler's List, which follows Oskar Schindler, a German industrialist responsible for saving hundreds of Jewish refugees during the Holocaust. The film was based on a real story. Spielberg directed the film, though he was reportedly deeply nervous to do so.
Black, White, and Red
One of the most interesting aspects of this film is the choice to film in black and white. The only time anything is in color is when a little girl in a red jacket appears onscreen. Of the choice, Spielberg once said "It was as obvious as a little girl wearing a red coat, walking down the street, and yet nothing was done to bomb the German rail lines."