Keanu Reeves, $262 Million
For all three Matrix films, Keanu Reeves made $262 million in total. He played the lead role, Neo, and the films are still in cultural relevance today. He's arguably never had a more influential role.
Johnny Depp, $300 Million
The Pirates of the Caribbean franchise earned Johnny Depp $300 million. The character of Jack Sparrow has influence far beyond the Disney films and has kept Depp in the business despite various personal scandals. No role has ever earned him as much success as Captain Jack.