The Lizard - Rhys Ifans
The Lizard in Spider-Man is obviously a huge CGI feat. Creating something that looks this good and supernatural in real life would be difficult. The incredible post-production work combined with Rhys Ifans' portrayal of the horrifying lizard man was a huge hit with the fans.
Ego - Kurt Russel
Kurt Russel plays Ego, the main villain in The Guardians of the Galaxy 2. Ego is Star-Lord's father, which complicates some things! Ego wants to take over the galaxy, but Star-Lord isn't going to let that happen. A huge chunk of this movie is CGI, including Ego's transformation.