Kaecilius - Mads Mikkelsen
Mads Mikkelsen is popular for his role as Hannibal Lecter in the Hannibal series, but he's also a famed character in Doctor Strange. He played Kaecilius, who is the main enemy against Doctor Strange himself. He starred alongside Benedict Cumberbatch.
Roark Junior - Nick Stahl
Roark Junior is probably the grossest villain out there. He's a sadistic killer and member of the powerful Roark clan in the film Sin City, which was adapted from a comic book. Nick Stahl played the character, who had to put on prosthetics to really fit the part.