Elena Anaya had the mask glued to her face during the entire day. That meant that she couldn't eat or drink anything until they wrapped for the day. She said that the process of putting it on and taking it off was painful, but it was worth it.
Voldemort - Ralph Fiennes
For an entire generation of people, Voldemort is the evilest villain in existence. Ralph Fiennes transformed into the character just like everyone else, minus the CGI makeup for the removal f his nose. What good would it do if He Who Must Not Be Named had a nose? That was the only CGI part of his transformation, everything else was real makeup.
Thanos - Josh Brolin
Thanos is the biggest villain in the extensive Marvel Universe. He quite literally comes crashing down in Avengers: Endgame. His goal? To capture all of the infinity stones so he can erase the entire universe. Josh Brolin plays the major villain, which is actually somewhat visible despite the fact that his entire get-up is CGI.