The Curious Case of Benjamin Button
Brad Pitt actually refused to kiss Cate Blanchett while they were filming The Curious Case of Benjamin Button. It wasn't because he disliked her; it was more because he didn't want to disrespect his wife at the time, Angelina Jolie. He ended up doing the kissing scene anyway!
The Lyon’s Den
Rob Lowe was adamant about casting Jewel to be his love interest on the show The Lyon's Den. Jewel agreed to star in the show but was also hesitant about the kissing scenes... She said it felt weird. She eventually agreed to kiss him even after asking for them to be scrapped altogether.