Thomas J. Sennett, My Girl
Nobody wants to see kids die on camera. In this coming of age film, Macaulay Culkin's character takes a back seat in the plot until he eventually passes away while searching for a mood ring that the main character loses in the woods. Having to witness a child cope with the death of a friend is enough to bring even the strongest person to tears.
Ellie, Up
It's seldom that a movie can make the viewer sob within the first couple of scenes, but Up is a little different from most movies. Pixar has always had a way to crush their viewers emotionally, and the relationship between Carl and Ellie set the tone of the movie almost immediately. Watching one of two lovers slip into serious illness hurts, but not as much as Ellie's inevitable death.