Salma Hayek, Versace Spring, 2001
After spending the entire 1990s being the most desired woman in movies, she crushed the early 2000s by instantly starring in movies like Frida and Once Upon a Time in Mexico. Her main focus was to bring her heritage to the big screen, and she succeeded later on in her career.
Kate Winslet and Jim Carrey, 2003
Eternal Sunshine of the Spotless Mind was one of Jim Carrey's most tame roles, despite being wildly abstract and energetic. In a film that helped define the 2000s, Carrey and Winslet play opposing characters, exes actually, that are actively being manipulated to remove one another from their memories.