Demi Moore
Everyone has to start somewhere—and for Demi Moore, that was at the bottom of the sci-fi horror bargain bin. Moore plays a lemon farmer named Patricia Wells living in post-apocalyptic America after a deadly parasite has been set loose on the nation. The film received largely negative reviews, but it has still been recognized as Moore's first major film role.
Naomi Watts
The Children of the Corn franchise served as a jumping-off point for plenty of actors' careers, and that includes Naomi Watts, who snagged the lead in the fourth installment, Children of the Corn IV: The Gathering (1996). Watts plays Grace Rhodes, a medical student who returns to her hometown right as a strange illness begins to afflict local children, including her sister. This direct-to-video film was one of Watts' first major roles, and she later went on to star in The Ring (2002).