Gravity
Gravity was four years in the making before it hit theaters—technology had to catch up to the film's vision. Sandra Bullock's costume was attached to wires, and a team manipulated the Oscar-winning actress like a marionette. The VFX was a monumental job, with every single scene requiring some amount of CGI.
Kill Bill
Uma Thurman was essentially a human puppet during the making of Kill Bill. However, it recently came to light that director Quentin Tarantino pressured Thurman into operating an unsafe vehicle for a pivotal scene without CGI or a green screen. Although production knew the car should have been driven by a stunt professional, Thurman relented, crashed the car, and injured herself profusely.