Vince Vaughn
Most people would say that Vince Vaughn was the first celebrity to be "canceled" in 2020. His inability to get out of 2000s humor partnered with his unnecessary political views dug out his grave for him. Before the 2020 scandals, he was already looking bad in the eyes of Hollywood producers.
Pigeon-Holed
He was seemingly unable to vary his acting abilities. Most people who tried to work with him would say that he flat out refused to grow as an actor, which is probably why he hasn't been in a decent movie for at least a decade. The recent scandals only pushed him deeper into the blacklist.