Moss is well-known for her role as Peggy but is also the star in The Handmaid's Tale, The Invisible Man, and Shirley. There's nothing that she can't do! In fact, she was named Queen of Peak TV by Vulture.
America Ferrera as Betty Suarez
Obviously, the main star in the show Ugly Betty has to be ugly (by society's standards, of course). Taking on the role of Betty was actually America Ferrera's breakthrough role. Betty was ambitious with unkempt hair and adult braces who was thrown into the fashion magazine world.
The main reason she was even given the job of assistant to the director of Mode Magazine was because of her looks. Mogul Bradford Meade knew that Betty's looks wouldn't be "disruptive" to her job, which was apparently a problem with other assistants. Of course, this becomes the main arc of the show and of Betty's growth as a character.
America and Betty
Ugly Betty was popular before social media was a trend. A lot of viewers were always shocked to see America Ferrera in reality. After all, she played the role of Ugly Betty so well that it was impossible to tell if she was real or not!